Certainly not enough to worry about! Once everything breaks in, mileage should improve. And that gasoline blend also makes a difference between tankfuls.
Bizarre...every Honda I've owned has gotten better gas mileage once it got over 100,000 miles. My '97 CR-V was rated as 22 city/25 highway, but on a drive to Columbus OH it got nearly 30 MPG. On a marathon drive from here to Bangor Maine, swinging through Boston (yes, I did it all in one day), I was averaging 26-27MPG and probably had 240-250k miles on it at the time.