The 2213 and 123A are very close (not quite identical) in acoustic performance. One of them (I think, from memory, it's the 2213) has a slightly longer voice coil winding, to mate with the different magnet assembly (2213 has a ceramic magnet, while 123A has an alnico magnet). That's about it, as far as significant differences are concerned... other mechanical differences include a larger outside-diameter spider on the 2213 (about 6.5" across as opposed to about 5.75" across on the 123A).
If replaced in pairs, these can easily be used "interchangably". I wouldn't use one each of each type in a pair of speakers (ie, a 123A in one side and a 2213 in the other), but as long as both are the same in a pair of speakers, the same crossovers and cabinet will give pretty much the same acoustic results, plus or minus a very small margin...
Regards,
Gordon.