Of the four, I've only owned the MC2300. [I've had about 20 of them over the years. I still have two.] The MC2300 is really just a big MC2505 in regards to sound. Many are taken with the sound of the first gen McIntosh SS amps, myself included. As twiiii mentions, the MC2300 is the only amp of the four that is designed to make rated power all day long (or 1/3 power for that matter). It also has the most output taps of any McIntosh stereo amplifier to date with .5, 1, 2, 4, 8, and 16 Ohm taps per channel. Incidentally, these taps permit operating the amp in mono into loads as low as .25 Ohms. So, the amps are equally at home driving loudspeakers, subwoofer systems, modulating sonar on battleships, or driving shake tables in industry. Yes, as CountD states, they do make in excess of 400 watts per channel. They're unique in many regards and I'm very fond of them personally as most here are well aware. I use my pair every single day.
I really know very little about the MC300 and it looks as if I may have erroneously assumed it was an MC7300 with an updated cosmetic package. I do have quite a bit of experience with the MC7300 but never owned one. Color me very impressed.
I do own other larger amps from the MC7300 (MC2600) and MC300 (MC500) eras. In comparison to my MC2300, I found the noise floor of the MC2600 to best it considerably so that's a definite nod in favor of the newer design. I'm also not sure I had ever heard my Altec speakers sound better than they do on the MC2600 - until of course, I bought the MC500. [I'm nowhere near an answer on whether I prefer the MC2600 or the MC500 . . . ]
There is constant discussion as to how the MC2300s sound when pushed to clipping. If you're pushing an MC2300 to clipping in your living room, you either have incredibly inefficient speakers or you've been influenced by peer pressure or alcohol - I'm certainly guilty on the last two counts although my speakers lived to tell about it the following day. In normal listening situations, even with very loud music, I just don't see that happening. twiiii reports ill side effects of this on tweeters in club installations when reckless DJs pushed systems to their limits but that's certainly understandable.
One thing to consider that you may have not already. The MC2300, MC7300, and MC300 can all be used in mono. So, if you decide that you need more horsepower or would like to try McIntosh mono blocks it's a simple as purchasing a second MC7300. That's FAR cheaper than buying a pair of MC501s or MC601s on the used market. Back in about 1995, I ran MC2300s mono to my Altecs and had a blast with that set up. I liked it so much, I ran it for a few years until I moved into a house that had a much smaller listening space. Honestly, I'm not sure if a pair of MC1000s would have been much of an upgrade, but who knows. Not many folks then were in a position to purchase the MC1000s so I always considered myself a bit on the cutting edge if you will.
To me, McIntosh amplifiers have a special something I've just not found in other amplifiers that I've owned. I'm sure in a few months, you'll be able to identify with this.