If you hear a faint hiss, it sounds like you have signal reaching your speakers. With no input signal and both volumes on the MC100 full out, you ought to hear a slight hiss. McIntosh amps are quiet, but not perfectly so. Try turning the volumes down one at a time and see if the faint sound drops out of the corresponding speaker.
If you are hearing hiss, it may be that you are not getting a signal to the amp from the C28. I assume you are patching a CD player, a tuner, a turntable or maybe a tape deck into the C28? The Aux input channel works well for an iPod. Check those connections. I have heard that some guys use "Brasso" to polish the RCA jacks on the back side and that they can really shine although I never tried that trick. But wiggle them a bit anyway. Same goes for the outputs on the C28. Those are the RCA from the L/R out to the input jacks in the MC250. Don't use the center channel. It does have a use, but if you are running just a simple 2-speaker stereo set-up you won't need it for now.
Once you get one set of speakers running, you may wish to spring for a speaker relay. The McIntosh SCR2A will wire in between the C28 and the MC100 and allow you to run 2 sets of speakers. The speaker selector push buttons on the front panel of the C28 are not much use without the relay, but they are easy to find and not too expensive.
May I ask, how did you come into this system? Some guys are lucky and inherit McIntosh goodies from a father-in-law or some such. If you can chat with whoever you got the system from, maybe they can tell you how to set it up.