I have an Autonomic MMS-5A, which from all appearances is what McIntosh uses in the MB100, with an upgraded DAC and different outputs.
I have my CDs recorded as AIFF files (44.1 kHz/16 bit) on iTunes, the iTunes "sync" program on my PC that automatically syncs the content, use the MMS-5A to stream my favorite FM stations from around the country (using the built in Tunein.com app) and my Spotify account, all controlled from my iPad.
I also have some hi-res music I purchased from HD Tracks in my iTunes library (192 kHz/24 bit).
I really enjoy the convenience and the sound quality is great (using USB digital output to the DAC in my McIntosh amp).
I suspect the McIntosh has all the great features of the Autonomic unit, with a better internal DAC.
I hear the price on the MB100 is $6500.
McIntosh MCD500, MAC6700, Totem Fire Monitors, Velodyne Optimum 10 Sub Woofer, Furman Elite 15, Wireworld Cabling, Sennheiser HD800 headphones