I am not sure where I belong in this discussion. But since I have four 2255s, two 2500s, two 7270s, and one 2205, I could not help myself from jumping in.
Right now at the office I am using MS750 feeding MX118 going through MEN220 which feeds the left and right lower frequencies through a pair of 2500s (one for each channel) and the left and right higher frequencies through a pair of 2255s (one for each channel). If I count watts correctly, I have 1500 watts each channel. (Need I say I must wait until "after hours" to really crank it up).
I have Legacy Signature IIIs with bi-amp capability (thus I can feed separate signals for upper register and lower register). I double wire each connection with 10 gauge speaker wire. Bi-amping and bi-wiring means four pairs of10 gauge wire runs to each speaker (eight wires in total). I am trying to have as little signal loss as possible in the 25 foot run from the power amps.
There is no problem when the cannons in Wellington's Victory come in.
BUT - for really close detail listening, I have Sennheiser 600s wired with balanced cables driven from the eight ohm taps from the MC2205. The detail through the Sennheisers driven in balanced mode by the MC2205 is the closest I have ever heard to being in a live orchestra pit.
In my early years I spent a lot of time in a live orchestra pit (50 piece amateur group) and "think" I know what to listen for.
HOWEVER - I am 71 - my hearing is not nearly as good as it used to be. Plus, I have pretty bad tinnitus (at about 2500hz) in my right ear. So, I cannot claim to be a good judge of various amps.
My 7270s are running in mono mode at home, each driving a separate channel in the home two channel system (MS300 to MX130 to "consumer" equalizer, to the pair of 7270s).
Given my limitation on hearing, do not use me as a "reliable resource." But - candidly - to me there is MUCH more difference in the speakers you are using than between any of the four amps (2500s, 2255s, 2205s, or 7270s).
As to whether output transformers (or autoformers as they are now called) are helpful or harmful,I think is it significant that McIntosh tried not using them, and then went back to using them. If they created a problem, McIntosh would not have gone back to using them.
Personally I like the 2255s (I have four of them). Probably because they were the last chrome chassis, they have power guard, speaker on/off switch, and headphone jack.
The biggest downside is weight. That probably puts the 2500s at the bottom of my list of favorites. I CANNOT lift one by myself. Since I have two 2500s, two 2255s, a 2205, a MX118, a MEN220, and a 3000KV double conversion Liebert power supply in the credenza behind my desk, I have to hire help every time something needs to be addressed from the back! I believe the fully loaded credenza unit probably weighs in at 700 to 800 pounds. Even with 12 rollers under the credenza, it really is a three man job to move it across the carpeting.
I don't think you can go wrong with any of the amps in this discussion.
Thanks for listening.
Jim